Formulation and Evaluation of Diclofenac Controlled Release Tablets Employing Olibanum Resin

The objective of the study is to evaluate Olibanum resin, a natural resin polymer as matrix polymer for controlled release tablets and to design matrix tablets of diclofenac for controlled release. Matrix tablets of diclofenac were formulated employing Olibanum resin in different proportions of drug and polymer and the tablets were evaluated for drug release kinetics and mechanism. Two diluents namely lactose (water soluble) and DCP (water insoluble) were included in the formulations to assess their influence on drug release characteristics of olibanum resin matrix tablets. Matrix tablets were found to be nondisintegrating in water, acidic (pH 1.2) and alkaline (pH 7.4) fluids and were considered suitable for oral controlled release. Diclofenac release from the matrix tablets formulated was slow and spread over 24 h and depended on the concentration (%) of olibanum resin in the matrix tablets and nature/type of diluent. As the concentration of olibanum resin in the matrix tablets was increased, drug release was decreased. Release was relatively faster with water soluble diluent lactose when compared to water insoluble diluent DCP at all concentrations of olibanum resin. Drug release from the tablets followed first order kinetics and followed non Fickian (anomalous) diffusion release mechanism. Good linear relationships were observed between percent polymer and release rate in each case. The results of the study thus indicated olibanum resin could be used as rate controlling matrix in design of controlled release tablets. Both water soluble and water insoluble diluents can be included in the olibanum resin matrix tablets without affecting its rate controlling efficiency. Matrix tablets formulated employing olibanum resin(DF2) are considered suitable for controlled release of diclofenac over 24 h (i.e. once-a-day administration). INTRODUCTION: Controlled release drug delivery systems are aimed at controlling the rate of drug delivery, sustaining the duration of therapeutic activity and/or targeting the delivery of the drug to tissue. Drug release from these systems should be at a desired rate predictable and reproducible. Among the various approaches, preparation of drug-embedded matrix tablets is one of the least complicated approaches for obtaining controlled release and is widely used in industry. The polymer used in matrix tablets plays a vital role in either controlling the drug delivery or enhancing bioavailability of the contained drug. Though a wide range of polymers are reported for preparing matrix tablets, there is a continued need to develop new, safe and effective polymers for controlled released matrix tablets. The objective of the present study is to evaluate olbinum resin as a matrix former for controlled release of Diclofenac. Correspondence to Author: